Philippians 4:6-7 (NASB)
6 Be anxious for nothing, but in everything by prayer and supplication with thanksgiving let your requests be made known to God.
7 And the peace of God, which surpasses all comprehension, will guard your hearts and your minds in Christ Jesus.
I often see people in my counseling office who need to find peace in difficult if not impossible circumstances. The people who believe in the God of the Bible not only have a promise of peace which transcends reason and circumstance, they are assured of a peace that “will guard (their) hearts and minds”. What a tremendous promise and hope for those who are “in Christ Jesus.”
Please read John MacArthur’s comments on this passage below. I believe it will encourage and inspire you.
"People become worried, anxious, and fearful because they do not trust in God's wisdom, power, or goodness. They fear that God is not wise enough, strong enough, or good enough to prevent disaster. It may be that this sinful doubt is because their knowledge of Him is faulty, or that sin in their lives has crippled their faith. Thankful prayer brings release from fear and worry, because it affirms God's sovereign control over every circumstance, and that His purpose is the believer's good.
Once the sinner has made "peace with God" (Romans 5:1), that is, in salvation having ceased to be God's enemy and become His child, he can enjoy the peace of God, the inward tranquility of soul granted by God. It is a confident trust in His flawless wisdom and infinite power that provides calm amid the storms of life. Isaiah wrote of this supernatural peace: "The steadfast of mind You will keep in perfect peace, because he trusts in You" (Isaiah 26:30).
Paul further defines this supernatural peace as that which surpasses all comprehension. It transcends human intellectual powers, human analysis, human insights, and human understanding. It is superior to human scheming, human devices, and human solutions, since its source is the God whose judgments are unsearchable and whose ways are unfathomable (Romans 11:33) . It is experienced in a transcendent calm that lifts the believer above the most debilitating trial. Since it is a supernatural work, it resists any human comprehension. The real challenge of the Christian life is not to eliminate every unpleasant circumstance; it is to trust in the good purpose of our infinite, holy, sovereign, powerful God in every difficulty. Those who honor Him by trusting Him will experience the blessings of His perfect peace.
When realized in believers' lives, God's peace will guard them from anxiety, doubt, and worry. PhroureĊ (will guard) is a military term used of soldiers on guard duty. The picture would have been familiar to the Philippians, since the Romans stationed troops in Philippi to protect their interests in that part of the world. Just as soldiers guard and protect a city, so God's peace guards and protects believers who confidently trust in Him. Paul's use of the phrase hearts and minds was not intended to imply a distinction between the two; he was merely making a comprehensive reference to the believer's inner person. Once again, Paul reminds his readers that true peace is not available through any human source, but only in Christ Jesus."
MacArthur New Testament Commentary, The - MacArthur New Testament Commentary – Philippians.
Having this kind of boundless resource in life is an incredible blessing that empowers believers to not only survive but to persevere and prevail over the obstacles this life often presents. As Christians, we avail ourselves to such power as we learn to find our purpose and meaning and indeed our life "in Christ". One way we can do this on a day to day basis is to follow the admonition of Philippians 4:6 and pray.